Recently, two genome-wide association studies identified that several genetic loci including rs493258 and rs10468017 (LIPC), rs3764261 (CETP), rs1883025 (ABCA1), and rs12678919 (LPL) were heavily implicated in HDL metabolism and might have the associations with AMD [11,42]. This evidence concerns the gene ABCA1 and age-related macular degeneration.