TNF and Arthritis: Non-canonical pathways exist in arthritis, whereby RANKL can be substituted by “homologous to lymphotoxins exhibiting inducible expression and competing with herpes simplex virus glycoprotein D for herpesvirus entry mediator (HVEM), a receptor expressed by T lymphocytes” (LIGHT), tumor necrosis factor α (TNFα), IL-6, IL-11 and IL-8 [51].