INS and pancreatic insulinoma: Moreover, the administration of low doses (0.0020 μM) of BPA in the rat insulinoma cell line (INS-1) decreases cell viability, enhances glucose-stimulated insulin secretion, insulin expression, and insulin content, whereas high BPA doses (0.20 and 2 μM) reduce glucose-stimulated insulin secretion and decrease the expression of genes involved in glucose-stimulated insulin secretion, such as glucose transporter 2 (GLUT2) and Gck, after long-term treatment (48 h) [63].