Other targets of miR-21 are associated with immunity and the pathogenesis of autoimmune diseases such as SPRY1 (Sprouty RTK Signalling Antagonist 1), GNAQ (Guanine Nucleotide-Binding Protein Alpha-Q), PLEKHA1 (Pleckstrin Homology Domain Containing Family A), and CXCR4 (C-X-C Chemokine Receptor 4) [108]. The gene discussed is SPRY1; the disease is autoimmune disease.