CASP3 and cancer: Following the activation of caspase-3 and alteration in expression of Bcl-2 family and C-myc, p53/p21 pathway-dependent or independent apoptosis was observed in breast MCF-7 cancer cells, and p53/p21 pathway-independent apoptosis can be observed in MDA-MB-231 cancer cells treated with saikosaponin A [115].