TNF and neoplasm: In addition, ginsenoside Rg3 induces immunogenic tumor cell death with induction of cytokine interferon-γ (IFN-γ) secretion and reduction of inflammatory cytokines IL-6, TNF-α, and TNF-β1, as well as enhances uptake of tumor cells by dendritic cells, indicating that ginsenoside Rg3 to be an effective immunotherapeutic agent [69].