CXCR4 and neoplasm: The main molecules involved in HSC and tumour cell migration are couple chemokine (C–X–C) receptor type 4 (CXCR4) and 6 (CXCR6) and their respective ligands, C–X–C motif chemokine ligand 12 (CXCL12) and 16 (CXCL16).