NCOA3 and metastatic malignant neoplasm in the lymph nodes: By univariate analysis, overexpression of SRC‐3 (P = 0.006), advanced tumor stage (P < 0.0001)), presence of lymph node metastasis (P < 0.0001), and advanced clinical stage (P < 0.0001) were significant negative prognostic factors for OS in ESCC patients (Table 2).