Given that SRC‐3 is known to coactivate other transcription factors such as E2F1, AP‐1, Ets‐2, and PEA3 to regulate the expression of cell cycle genes, and these transcription factors have been implicated in ESCC, further work is needed to investigate the potential link between these transcription factors and SRC‐3 and their possible role in the pathogenesis and progression of ESCC 18, 25, 26, 27, 28, 29, 30, 31. The gene discussed is NCOA3; the disease is esophageal squamous cell carcinoma.