In this study, the results of another larger cohort of ESCCs analyzed by IHC validated our previous findings that SRC‐3 was frequently overexpressed in ESCC tissues and it was significantly correlated with advanced tumor stage and seemed to be more common with advanced clinical stage, suggesting that the upregulated expression of SRC‐3 in ESCC may facilitate the invasive phenotype. This evidence concerns the gene NCOA3 and esophageal squamous cell carcinoma.