In contrast, the expression of ERα (69, 49.6%), ERβ (122, 72.2%), and p53 (42, 33.8%) in tumor tissues was significantly higher than those (2.2%, 60.3%, and 4.3% for ERα, ERβ, and p53, respectively, detailed data for normal mucosal not shown) in uninvolved mucosal tissues (P < 0.01). Here, ESR2 is linked to neoplasm.