However, loss of function mutation of BRCA1 and p53 genes drastically increase the risk of BC and can disrupt the function of PI3K/AKT and ATM/ATR signaling (Abramovitch & Werner, 2002; Abramovitch et al., 2003; Miller et al., 2005; Vivanco & Sawyers, 2002). Here, TP53 is linked to breast cancer.