TLR8 and synovial sarcoma: The modulatory effect of TLR activation in the cytokines response in SS has been showed by the activation of peripheral blood mononuclear cells (PBMC) using the TLR7 agonist (3M-001), which induces increased levels of IFN-α production, and the TLR8 agonist (3M-002), inducing IL-12 and IFN-γ [16].