Our findings reveal a dysfunctional cytokine response upon TLR activation in SS patients; indeed, the TLR2/TLR4 agonist was able to partially restore IL-6, TNF, IL-10 and IL-13 production, while TLR7/8 showed an adjuvant effect on IFN I and II, IL-10 and pro-inflammatory cytokine secretion. Here, TNF is linked to synovial sarcoma.