In addition, silent mating type information regulation 2 homolog 1 (sirtuin 1, SIRT1), is an NAD-dependent deacetylase for modulating cellular metabolism, extending lifespan, and delaying the onset of a number of neurodegenerative disorders including AD [11], which is confirmed to be a direct target of miR-34a [12]. The gene discussed is SIRT1; the disease is Alzheimer disease.