In conclusion, DHM can ameliorate cognitive impairments in D-gal-induced aging rats by the induction of autophagy in hippocampus tissues through suppressing aging-related astrocyte activation and inhibiting mTOR signal pathway as well as down-regulating miR-34a, which provides the important theoretical supports of DHM for preventing or treating aging-associated neurological disorders. This evidence concerns the gene MTOR and nervous system disorder.