Previous preclinical and clinical studies proved that zoledronic acid could be an anti-angiogenic agent, which could inhibit proliferation of HUVEC endothelial cells, suppress expression of VEGF in A549 NSCLC line (with G12S-mutant KRAS), and cause decreased level of VEGF in the circulation of cancer patients [19, 35]. Here, KRAS is linked to non-small cell lung carcinoma.