After the tumors were dichotomized into those with low and high MCM10 expression (Table 2), high MCM10 was significantly associated with increased tumor stage (both UTUC and UBUCP<0.001), higher histological grade (UTUC P<0.001; UBUC, P=0.003), lymph node metastasis (UTUC, P=0.002; UBUC, P=0.004), vascular invasion (UTUC, P<0.001; UBUC, P=0.001), perineurial invasion (UTUC, P<0.001; UBUC, P=0.021) and frequent mitosis (both UTUC and UBUCP<0.001). The gene discussed is MCM10; the disease is metastatic malignant neoplasm in the lymph nodes.