GSK-3β is also the case and we previously reported that the pharmacological GSK-3β inhibitors (AR-A014418, SB-216763) inactivate GSK-3β in cancer cells within an hour after treatment and that the GSK-3β-specific siRNA takes longer than 48 hours to efficiently, but not completely, deplete GSK-3β expression in the same cells [38]. The gene discussed is GSK3B; the disease is cancer.