Thus, the reduced GAD67 immunoreactivity in the striatum of middle-aged T2D GK rats could point towards an abnormal decrease in striatal GABA levels and impairment of inhibitory modulation of striatal neuronal activity in these animals, which in turn could be speculatively linked to early sensorimotor complications in T2D or delayed recovery after stroke [52]. This evidence concerns the gene GAD1 and type 2 diabetes mellitus.