The transcriptionally regulated panel of genes and their interactions correlate with the formation of structural and functional components of polarized follicles, and this could have great relevance in other organs, such as the kidney, where Pax8 is highly expressed and Cdh16 is involved in the later stages of tubulogenesis (Thedieck et al., 2005), as well as in 3D MDCK cyst formation (Gálvez-Santisteban et al., 2012). The gene discussed is PAX8; the disease is cyst.