Of the significantly distributed alleles with frequency greater than 1%, six alleles (B54, B15, B40, DRB1*4, DRB1*11, and DRB1*10) show significantly higher frequencies in uremia patients, and two of the six (DRB1*4 and DRB1*11) belong to the top seven frequent alleles which may be risky alleles for uremia. This evidence concerns the gene HLA-DRB1 and uremia.