In contrast, crqko flies showed no significant difference in constitutive or infection induced expression of Drs, but showed an increased expression of Dpt with age, and infection induced an increased and chronic expression of Dpt. Altogether our results argue that phagosome maturation defects in crqko flies lead to persistence of bacteria and thus to an increased and persistent systemic immune response via the Imd pathway. This evidence concerns the gene DPT and infection.