In addition, a 38-kDa protein band, likely a cleavage product (Cp) of FBP1, appeared at Hour 4 and reached a maximal level at Hour 6; moreover, a potential 30-kDa Cp of FBP1 appeared at 8 and 10 hours post-infection, demonstrating that EV71 infection destabilizes FBP1 (Fig 1E). This evidence concerns the gene FBP1 and infection.