In the present study, we confirm that the the abundance of LIM-only protein LMO4 and LIM domain-binding protein LDB1 are frequently increased in carcinoma of the head and neck and suggest that their aberrant expression is mediated at a post-translational level by two single-stranded DNA-binding proteins, SSBP2 and SSBP3. Here, SSBP2 is linked to carcinoma.