Here, we demonstrate that LMO4 and LDB1 expression correlated closely with that of SSBP2 and SSBP3 in a panel of human oral cavity carcinoma cell lines, that these proteins were concordantly expressed in oral cavity and oropharyngeal tumor primaries and lymph node metastases, and that LDB1 gene inactivation significantly inhibited cellular invasiveness and proliferation and tumor angiogenesis. This evidence concerns the gene LDB1 and oral cavity carcinoma.