EGFR and neoplasm: In the pilot dataset, gCIMP status was associated with IDH1 mutation (p = 1.6 x 10−7), oligodendroglial histopathology (p = 0.0015), and strong expression of p53 (indicative of mutation[23], p = 0.031), and was inversely associated with tumor grade (p = 1.53 x 10−5) and EGFR amplification (p = 0.0014) (Table 1).