When investigating the relation between glioma risk variants and DNA methylation in promoter regions of nearby genes, we found an association between a glioma risk variant localized in TERT, rs2736100, and lower methylation of cg23827991, a CpG probe localized close to the first exon of an alternative TERT transcript (uc003jbz.1). This evidence concerns the gene TERT and central nervous system cancer.