We performed bilateral lentiviral overexpression of TRIM28 in pre-symptomatic mouse models of synucleinopathy (Rockenstein et al., 2002) and tauopathy (Yoshiyama et al., 2007) and found that injection with TRIM28, but not control lentivirus, worsened each aspect of neuropathology tested in both models (Figure 4A,B; and Figure 4—figure supplement 1A,B). The gene discussed is TRIM28; the disease is tauopathy.