Remarkably, compound 1 at 10 and 20 mg/kg dramatically reduced biochemical (IL-6 and lung MPO activity) and histological (edema and inflammatory scores) responses of ALI in NaT-AP (Fig. 8); more significant reduction by high dose in MPO activity, edema and inflammatory infiltrate; 55.69%, 78.94%, and 76.63% down to the control levels, respectively (Fig. 8b–e). Here, IL6 is linked to acute respiratory distress syndrome.