CORO1A and neoplasm: According to a univariate analysis, a tumour size >5 cm (hazard ratio [HR] = 3.083, 95% confidence interval [CI] = 1.008–9.434, P = 0.048), HBV DNA > 6.0E+06 copies/ml (HR = 4.283, 95% CI = 1.240–14.796, P = 0.021), TACO mutations (HR = 2.815, 95% CI = 1.010–7.846, P = 0.048), a higher HBsAg titre (HR = 3.987, 95% CI = 1.237–10.712, P = 0.021), and strong pAKT1 expression (HR = 3.896, 95% CI = 1.308–11.605, P = 0.01) were associated with significantly increased mortality due to HCC.