CORO1A and neoplasm: However, the apoptotic index inversely correlated with the levels of pAKT and TACO mutations in human HCC (3.0 vs. 3.8 for high pAKT and low pAKT tumours, respectively, P = 0.046; and 4.0 vs. 5.3 for TACO positive and TACO negative tumours, respectively, P = 0.041) (Fig. 3d).