CXCL8 and cancer: The top pathway in Ingenuity analysis of the 805 differentially expressed proteins was related to cytoskeletal reorganization, followed by several RHO-associated processes, endocytosis and cell trafficking, cell junction associated pathways, and biological pathways known to be activated in cancer i.e. PI3K/AKT, IL8, aryl hydrocarbon receptor, CXCR4, Cdc42, and PAK (Supplementary Table 6).