CXCL1 and infection: Consistent with our in vivo findings of diminished CXCL1 in BAL from Nlpr12−/− mice following infection with F. tularensis LVS, we observed that Nlpr12−/− BMDM secreted significantly less CXCL1 in response to F. tularensis LVS, S. aureus and P. aeruginosa (Fig. 7b).