Histological evaluation of pancreatic tumors demonstrated increased expression of nuclear pS139-H2AX in the pre-neoplastic lesions (acinar-to-ductal metaplasia, ADM, pancreatic intraepithelial neoplasm, PanIN) and in the invasive adenocarcinoma (PDAC) following a single dose of STA-12-8666 or irinotecan (Figure 2D, Supplementary Figure S1) compared to vehicle. The gene discussed is H2AX; the disease is pancreatic neoplasm.