Our study showed that the positive expression rate of PTEN, PIK3C2A, ITPA and BCL3 in 174 cases of ccRCC were 48.9% (Figure 2A), 63.8% (Figure 2B), 34.5% (Figure 2C) and 23.6% (Figure 2D), respectively. The gene discussed is PTEN; the disease is nonpapillary renal cell carcinoma.