HMGB1 and melanoma: The A375 and SK-28 melanoma cells were treated with exogenous Hmgb1 at 0.01 μg/ml, 0.05 μg/ml, 0.1 μg/ml, and 0.5 μg/ml of Hmgb1 protein with or without 100 μM of NF-κB inhibitor CAPE for 24 and 48 hrs.