FMR1 and autism: To further characterize the Mef2c cKO DEGs, we compared our gene list with the recently updated risk genes from the Simons Foundation Autism Research Initiative (SFARI database, 667 genes) (Basu et al., 2009), mRNAs associated with FMRP (Darnell et al., 2011), ID-associated genes from multiple sources (Inlow and Restifo, 2004; Lubs et al., 2012; Ropers, 2008; van Bokhoven, 2011), and synaptic-associated genes (Synaptome DB) (Pirooznia et al., 2012).