SHANK2 and autism: Among all the dysregulated genes, we observed significant overlap of Mef2c cKO DEGs and autism-linked genes (78), synaptome genes (191), and FMRP-target RNAs (110), many of which are associated with multiple disease and neuronal function groups (Figures 4B and Figure 4—figure supplement 1C), including Nlgn1 (ASD, Synaptome), Nrxn1/3 (ASD, Synaptome, FMRP-bound RNAs), Grm4 (ASD, FMRP-bound RNAs), and Shank2/3 (ASD, Synaptome, FMRP-bound RNAs).