MEF2C and neurodevelopmental disorder: We also show that MEF2C likely regulates E/I synapse density by functioning as a cell-autonomous, transcriptional repressor, and that Mef2c loss-of-function in Emx1-lineage populations produces, directly or indirectly, a dramatic dysregulation of hundreds of neuronal genes, positioning it at the nexus of numerous critical neurodevelopment genes reported to influence neuronal and synaptic development and risk for neurodevelopmental disorders.