The most prominent infiltration was by CD4+ and CD8+ T cells, there being a threefold increase for CD4+ T cells and a twofold increase for CD8+ T cells in the peritumoural stroma compared with the intratumoural (tumour cell nests) compartment (45.6 [6.8–242.0] versus 15.4 [2.6–171.0] and 43.6 [1.8–201.6] versus 20.2 [3.4–202.4]), respectively (Table 5) (Figure 2). This evidence concerns the gene CD4 and neoplasm.