There was a significant reduction of FOXP3+ T cells in the blood (% [p = 0.001], absolute numbers (AbNs) [p = 0.001]) and breast cancers (intratumoural [p = 0.001], stromal [p = 0.001]) following 8 cycles of NAC in the same cohort of 16 patients (Table 6). The gene discussed is FOXP3; the disease is breast cancer.