After NAC, however, there was a significantly higher % of blood FOXP3+ T cells and significantly higher levels of intratumoural (tumour cell nests) FOXP3+ T cells in those women whose tumours had a poor pathological response to 8 cycles of NAC (p = 0.001 and p = 0.016, resp). The gene discussed is FOXP3; the disease is neoplasm.