Current evidence in experimental models with impaired insulin signaling exhibited both metabolic and bone phenotypes, including obesity, insulin intolerance/resistance, and symptoms of low bone mass [6] and the qualitatively different effects of T1D and T2D on bone mass are consistent with the opposing insulin-secretory states [hypoinsulinaemia versus hyperinsulinaemia] [7]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.