TNF and type 2 diabetes mellitus: As shown in Figures 2, , , , , –8, both T2DM patients with complication and the patients without complication had significantly increased levels of serum IL-6 (Figure 2), TGF-β (Figure 3), and TNF-α (Figure 4), while not significant changes were found in the percentage of peripheral CD4+CD25+Treg (Figure 7) and IL-17 (Figure 8).