In addition, we observed that ceramide and DAG muscle content and subspecies, except for ceramide 22:0 subspecies, were not affected by 10 weeks of training in Offspring of type 2 diabetic patients and matched Control subjects, though a clear training induced increase in insulin sensitivity and maximal oxygen uptake as well as increased citrate synthase and cytochrome oxidase activity, as previously described [33]. The gene discussed is INS; the disease is type 2 diabetes mellitus.