SLC5A8 and cancer: Ueno et al. demonstrated that SLC5A8 was downregulated in adults with gastric cancer (Ueno et al., 2004) and was silenced in ~60% of individuals with colorectal cancer (Keenan and Frizelle, 2014), and others have confirmed that it is downregulated in several cancer types, including stomach (Ueno et al., 2004; Ganapathy et al., 2008), colon (Li et al., 2003; Miyauchi et al., 2004; Thangaraju et al., 2008), thyroid (Ganapathy et al., 2005; Porra et al., 2005; Schagdarsurengin et al., 2006), and breast (Thangaraju et al., 2006, 2009; Coothankandaswamy et al., 2013; Elangovan et al., 2013).