It was previously reported that Nav1.7 expression was increased in animal models of inflammation (Black et al. 2004; Chattopadhyay et al. 2008), diabetes (Chattopadhyay et al. 2008, 2011) and CCI (Liu et al. 2012), and a monoclonal antibody that targets Nav1.7 was reported to reduce inflammatory and neuropathic pain in mice (Lee et al. 2014). This evidence concerns the gene SCN9A and diabetes mellitus.