ANXA5 and cardiovascular disorder: Several distinct types of PCD have been defined, including apoptosis, necroptosis and autophagy, as well as several other forms.1–3 Necroptosis is currently viewed as the dominant mode in forms of inflammation.4 The intracellular pathways that characterize different forms of PCD and their cross interactions have been reviewed recently.5,6 Early events in PCD include externalization of phosphatidylserine to which annexin V binds and signals to phagocytes.7 However, imaging with annexin V is also useful to visualize inflammation and cell stress in the context of cardiovascular disease.8