When comparing gene expression in 114 breast cancer patients that received anthracycline chemotherapy and 1062 breast cancer patients that did not receive chemotherapy, anthracycline therapy increased type 1 immune response, and the increased CD8+ (HR 0.72 95 % CI 0.59 to 0.82 p = 0.005) and IFN-g (HR 0.56 95 % CI 0.56 to 0.89 p = 0.016) expression was associated with improved pCR in patients that had been treated with anthracycline [46]. This evidence concerns the gene CD8A and breast cancer.