<h4>Background</h4>Population studies showed that patients with JAK2 V617F mutation had increased mortality, and increased risk of any cancer, hematologic cancer, and myeloproliferative disease.<h4>Case presentation</h4>A 68-year-old Asian male with JAK2 V617F mutation developed four different hematologic and non-hematologic neoplastic processes. This evidence concerns the gene JAK2 and hematopoietic and lymphoid cell neoplasm.