It seems that there is a negative association between ghrelin and insulin concentrations in adults.23,27 In children, total ghrelin have been shown to be positively associated with insulin resistance, independently of anthropometric and metabolic variables.22 It has shown that hyperinsulinemia may result in decreasing circulating ghrelin independently of glucose.28 Interestingly in our study, LDL and HDL had significant correlations with ghrelin in children without MetS. The gene discussed is INS; the disease is hyperinsulinism.