Successful desensitization can be achieved in patients with IgE/mast cell mediated hypersensitivity reactions (allergy to beta lactams or other antibiotics) [219] and platinium salts [220, 221] who present symptoms including urticaria, angioedema, wheezing, laryngeal edema, nausea, vomiting, diarrhea or hypotension. This evidence concerns the gene IGHE and allergic disease.