CDSN and Alzheimer disease: Although a case–control study evaluating polymorphisms across 21 EDC genes in a German cohort did not find evidence for associations apart from FLG, several transcriptomic profiling studies have reported that EDC genes of IVL, LOR and LCE2B, and the cell–cell adhesion protein, CDSN, were significantly down-regulated in AD skin lesions, suggesting that elevated inflammatory cytokines in the disease loci also play an important role for dysregulation of epidermal barrier genes [42, 43].