EMSY and Alzheimer disease: This study replicated FLG locus as an AD predisposing factor and identified a novel susceptibility region at chromosome 11q13.5 located 38 kb down-stream of C11orf30. Two year later in 2011, Sun et al. reported a GWAS study on Chinese Han population, FLG region was once more validated in Chinese population and two novel loci of 5q22.1 and 20q13.33 were identified.