Research from our group also uncovered the association of saliva FOXP3 methylation with TRAP exposure during the 1st year of life and persistent wheezing and asthma diagnosis at age 7 in the CCAAPS cohort [144], which implicates the epigenome as a mediator of the impact of early life TRAP exposure on later asthma risk. This evidence concerns the gene FOXP3 and asthma.