This study provides the first evidence that overexpression of lncRNA DBCCR1-003 inhibits BC growth through the inducing G0/G1 arrest and apoptosis, and the expression of DBCCR1 may be regulated by DBCCR1-003 via binding to DNMT1 and preventing DNMT1-mediated the methylation of DBCCR1. This evidence concerns the gene BRINP1 and breast cancer.