In the multivariate analysis of the prognostic factors, we confirmed that high TPX2 expression was an independent prognostic factor (95 % CI 2.626–7.198; P = 0.001), and age, tumor size, and N stage were also independent and significant prognostic factors for OS (P = 0.046, 0.005 and 0.000). This evidence concerns the gene TPX2 and neoplasm.