Therefore, we have supplemented our data with APA versus phaeochromocytoma although these also may have their own paracrine effect of the adenoma.47 Considering that the reported difference of CYP11B2 expression in normal ZG versus ZF, harvested from healthy renal transplantation donors, is also only about 2-fold (as seen by the microarray results for the four ZG samples),4 it seems that the aldosterone production in human ZG, whether normal or adjacent to a pheochromocytoma or an APA, is suppressed. The gene discussed is CYP11B2; the disease is adenoma.