TWIST1 and cancer: Further study of WHSC1 in cancer cell lines strengthens the link between WHS and aberrant cell migration, as the WHSC1 methyl-transferase activity has been shown to exert epigenetic control over the expression of Twist family proteins, transcription factors that regulates epithelial-to-mesenchymal transition (EMT) in normal development, as well as in cancer cells (Ezponda et al., 2013; Kuo et al., 2013; Yang et al., 2004; Fig. 2B).