LETM1 and Wolf-Hirschhorn syndrome: Recently, Doonan et al. have observed altered mitochondrial calcium influx and eflux, mitochondrial bioenergetics, and metabolic signaling when LETM1 is silenced in multiple organisms and cell types, including in cells derived from WHS patients; they also report AMPK activation and increased mitochondrial ROS production (Doonan et al., 2014a).