ANXA5 and acute lymphoblastic leukemia: In response to treatment with 5 μM nelarabine (2 μM for MOLT-4 cells), we detected a marked increase in the percentage of early apoptotic (positive for Annexin V) and/or late apoptotic (positive for both Annexin V and PI) cells after 48 h of treatment of T-ALL cell lines MOLT-4, JURKAT, P12-ICHIKAWA, and DND41 (Fig. 2a).