Additionally, high baseline serum S100A8/A9 levels in JIA are predictive of a good response to methotrexate and anti-TNF treatment [46, 47], whereas high serum levels of S100A8/A9 after complete remission can predict a relapse of inflammatory flares [12, 47, 48]. The gene discussed is S100A8; the disease is juvenile idiopathic arthritis.