Comparison of the differently expressed genes among WT, IFNAR−/− astrocytes, supernatant or IFNαB/D-treated WT astrocytes showed an overlap of 112 transcripts, and these transcripts might be of particular importance as most of them were downregulated in IFNAR−/− astrocytes, which were highly susceptible to TBEV infection, whereas they were upregulated in supernatant- and IFNαB/D-treated cells, which were resistant to the infection. This evidence concerns the gene IFNAR1 and infection.